Selective targeting
Procyanidin C1 recognised senescent cells and acted on them while leaving healthy cells largely untouched.
The science
The Mediterranean diet,concentrated
Researchers looking into why Mediterranean populations live longer keep returning to procyanidins — the polyphenols in grape seeds, olive oil and dark chocolate. PCC1™ concentrates these compounds and pairs them with a delivery system built to help them absorb.
- Studied compound
- Procyanidin C1, a natural senolytic
- Found in
- Grape seeds, olive oil and dark chocolate
The problem
Zombie cells
As we age, damaged cells stop clearing and start to linger. These senescent “zombie” cells release inflammatory signals that wear on the healthy tissue around them — the way one bad apple spoils the bunch.
Senolytics are compounds that support the body’s natural clearance of these cells. Procyanidins are among the most studied of them.
50+
Peer-reviewed studies on procyanidins
Nature Metabolism, 2021
What the research found
A team publishing in Nature Metabolism tested procyanidin C1 and reported three results worth knowing.
64%
Maximum lifespan in aged mice
In mice already old when treatment began — 24 to 27 months, roughly 70 human years — maximum lifespan rose by 64%.
Physical function
Treated aged mice showed measurable gains in strength and physical performance.
This was a preclinical study in mice, and human clinical trials are ongoing. PCC1™ gives you access to the same compound the researchers studied. Read the Nature study
The formula
The PCC1™ formula
Three procyanidins in a considered ratio, built for absorption. Findings about isolated procyanidin C1 informed the formula; PCC1™ is the finished product you take.
Trimer
Procyanidin C1
The primary active. A grape-seed trimer studied for its effect on senescent cells.
Dimer
Procyanidin B2
A dimer that works alongside C1. Abundant in cocoa and apples.
Monomer
Epicatechin
A monomer that rounds out the blend. Found in dark chocolate and green tea.
About 5.7× better absorption
Procyanidins are notoriously hard for the body to absorb, and high-dose botanical extracts are difficult to keep clean. PCC1™ uses a purified isolate in a phospholipid (phytosome) complex. In our measurements, that delivery format achieves about 5.7× better bioavailability than standard grape-seed extract.
The difference
Concentrated, not diluted
Most procyanidin supplements are ground grape-seed extract in a capsule. PCC1™ takes a different route.
Active compounds
- Generic grape-seed extract
- A whole-plant extract whose procyanidin content shifts from batch to batch.
- PCC1™
- Procyanidin C1, B2 and epicatechin in a fixed, standardised ratio.
Absorption
- Generic grape-seed extract
- Polyphenols pass through the body largely unabsorbed.
- PCC1™
- About 5.7× better bioavailability vs standard grape-seed extract, in our measurements.
Purity
- Generic grape-seed extract
- High-dose botanical extracts are hard to control for contaminants.
- PCC1™
- A defined isolate with published SGS and Eurofins reports.
How you take it
- Generic grape-seed extract
- Every day, indefinitely.
- PCC1™
- Three days a month, then rest.
Laboratory reports for the tested material are published on the quality page.
The protocol
Three days a month
Senolytics are studied as short, spaced pulses rather than daily doses. PCC1™ is one 30-day cycle: three days on, then twenty-seven days of rest.
Days 1–3
Take one sachet — three capsules — once daily, with food and water.
Days 4–30
Take nothing further. Let your body respond over the rest of the cycle.
Before you start
One 30-day cycle per box. Speak with a qualified healthcare professional if you take medication, have a medical condition, or are pregnant or breastfeeding.
Ready to start?
One box is one 30-day cycle: three days on, twenty-seven days off.
PCC1™ is a food supplement, not a medicine, and is not intended to diagnose, treat, cure or prevent any disease.